"I found something that "works" but it's not really a fix and is really really annoying," posted Resterix, who with his wife and a friend all had factory-unlocked iPhone 4S models. "If I turn off 3g and cellular data, and then do a hard restart of the phone, we can go all day and only lose about 15% of battery life. Once I turn 3g or cellular data on, even with all apps closed, we'll lose 1% every 3-5 minutes on standby."
He describes a maddeningly manual sequence of events: "So, if i'm out and want to use data, I have to go into settings, turn on 3g and cellular data. Do the thing I wanted to do. Then, go back into settings, turn off 3g and cellular and then do a hard restart.. I am thinking it has something to do with the factory unlocked iphones, as my friends who have carrier locked phones don't seem to have any battery issues."
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